“…provides an up–to–date overview of the different phases of drug discovery and preclinical development of experimental cancer principles.” (Drug Discovery & Development, September 2004)
“…benefits source: strong writing and a gifted use of analogy to introduce the abstract issues…perfect for a novice…” (Journal of Chemical Education, Vol. 80, No. 9 September 2003)
“…an excellent introductory text…” (Journal of Proteome Research, Vol. 2, No. 2, March/April 2003)
“…this welcome addition to the introductory crystallographic literature should be well received…recommended…” (Choice, Vol. 40, No. 8, April 2003)
“…an excellent introductory text…” (Journal of Proteome Research, Vol. 2, No. 2, March/April 2003)
“…this welcome addition to the introductory crystallographic literature should be well received…recommended…” (Choice, Vol. 40, No. 8, April 2003)
“…I highly recommend this book…in fact, I foresee it finding its way to the bookshelves of many faculty members, albeit with frequent removal for consultation as an educational tool!” (Clinical Chemistry, Vol. 49, No. 7, 2003)
“…excellent and clear introduction…in an easily readable and conversational style it explains many essential principles and methods very effectively…” (Angewandte Chemie International Edition, Vol 42(37), 2003)
From the Back Cover
Crystallography has become the keystone of rational pharmacology, protein engineering, structural genomics, proteomics, bioinformatics, and nanotechnology. By growing molecules in three–dimensional crystal forms, researchers can determine precise molecular structure, leading to major advances in biotechnology applications such as improved drugs and crops. Introduction to Macromolecular Crystallography provides a comprehensive, approachable summary of the field of crystallography, from the fundamental theory of diffraction and properties of crystals to applications in determining macromolecular structure.
Dedicated to providing a complete introduction to the subject that does not assume a background in physics or math, the book’s contents flow logically from basic principles to key methods, such as those for solving phase problems, interpretation of Patterson maps, and the difference Fourier method. The Introduction includes practical instruction on the interpretation of data and methods for determining phases and also:
- Illustrates concepts throughout to clarify difficult ideas
- Integrates analogies to illuminate the text
- Presents a nontechnical, approachable style, ideal for biologists, biochemists, and students
- Equips the reader to employ the range of programs in crystallography
Biochemists, molecular biologists, and pharmacological scientists, as well as advanced undergraduate and graduate students in molecular and cell biology, biochemistry, and biophysics, will find Introduction to Macromolecular Crystallography an invaluable introduction to this pivotal field.
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