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War in the Body: The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines Softcover reprint of the original 1st ed. 2013 Edition
Author(s): W David Wick (Author), Otto O Yang (Author)
- Publisher: Springer
- Publication Date: 5 Aug. 2015
- Edition: Softcover reprint of the original 1st ed. 2013
- Language: English
- Print length: 317 pages
- ISBN-10: 1489992553
- ISBN-13: 9781489992550
Book Description
In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus’s evolution, and the implications of these for vaccine development. The issue will be explored and explained through “ecological genetics,” which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of “population genetics,” which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.
Editorial Reviews
Review
From the reviews:
“Provide a critical overview of the mathematical modeling performed so far to understand HIV immunity and escape, and advance an innovative alternative approach for stochastic simulation. … War in the Body is not a how-to guide, tutorial, or cook-book, but a research monograph, with thought exercises to cultivate problem-solving skills and foster developing plausible, stable numerical simulations.” (Complexity, March, 2014)
About the Author
Dr. Yang is a well known T-Cell and HIV expert at UCLA. Dr. Wick is recently retired. His last position was Senior Scientist in the Infectious Diseases Division of the Fred Hutchison Center, in Seattle, where he worked on immune response to HIV and vaccines.
