“The book appropriately starts with a discussion of interpreting breath analyses, and readers quickly learn that the lack of standardization for specimen collection, patient preparation, or laboratory analytical methodology has greatly limited its applicability to assessing human health or disease…This book nicely summarizes the current state of the art of VOC detection and analysis for a variety of interesting applications.” –Doody.com, November 2013
“Volatile organic compounds are continuously generated by the human body and partially emitted in exhaled breath and through the skin, as well as other pathways…Medical, biological, chemical, and engineering specialists review developments in breath analysis since 2005, when the previous volume was completed.” –Reference & Research Book News, October 2013
From the Back Cover
Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine provides a comprehensive review of the use of volatile organic compounds (VOCs) generated through normal physiology or pathophysiology that are present as biomarkers in exhaled breath, other bodily excretions, and emitted via skin. These volatile metabolites carry valuable information on the metabolic status or disease activity in healthy people and patients alike. Their role in clinical diagnosis, therapy, and safety is an emerging multidisciplinary area of study that shows great promise for non-invasive and low-cost point-of-care monitoring of many common diseases such as cancer, respiratory and gastrointestinal dysfunction, nutritional intolerance and metabolic disorders, including diabetes.
This book:
- Gives first-hand accounts of discoveries and the potential significance of VOC metabolites by the world’s foremost scientists and clinicians in the field and synthesizes the growing literature in this area.
- Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of VOCs.
- Includes information on the latest instrumentation and technology such as proton transfer reaction- and selected ion flow tube-mass spectrometry (PTR-MS and SIFT-MS) and electronic noses, and provides examples of their potential significance in clinical diagnosis.
- Includes case presentations documenting the role of volatile biomarkers in many areas of human health and safety.
- Includes suggested models for standardizing sample collection and highlights new ways of identifying and quantifying VOCs in exhaled breath.
- Reviews endogenous volatiles in exhaled breath and those emitted by other biological media that are potential biomarkers for diseases such as cancer and diabetes.
About the Author
Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems and biomarker identification in agriculture and humanimal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR.
Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member and current treasurer of the International Association of Breath Research (IABR).
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