The Pauson-Khand reaction is an important reaction in the field of organic chemistry. It involves the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to produce cyclopentenones. The importance of this reaction originates from its high value in transforming simple components into the synthetically useful cyclopentenone unit, in which a high degree of molecular complexity can be achieved in a single step, with impressive stereochemical and regiochemical control.
The Pauson-Khand Reaction investigates the nature and many variations of this reaction, including:
- the mechanism of the Pauson-Khand reaction
- non-chiral Pauson-Khand reactions
- diastereoselective Pauson-Khand reactions
- asymmetric Pauson-Khand reactions using chiral auxiliaries
- enantioselective Pauson-Khand reactions
- recent advances in catalytic Pauson-Khand reactions
- the Pauson-Khand reaction in total synthesis
- heterogenous catalytic Pauson-Khand reactions
- other carbonylative cyclizations leading to cyclopentenones
Presenting a comprehensive overview of this fundamental reaction, The Pauson-Khand Reaction will find a place on the bookshelves of any organic or organometallic chemist.
The Pauson-Khand reaction is an important reaction in the field of organic chemistry. It involves the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to produce cyclopentenones. The importance of this reaction originates from its high value in transforming simple components into the synthetically useful cyclopentenone unit, in which a high degree of molecular complexity can be achieved in a single step, with impressive stereochemical and regiochemical control.
The Pauson-Khand Reaction investigates the nature and many variations of this reaction, including:
- the mechanism of the Pauson-Khand reaction
- non-chiral Pauson-Khand reactions
- diastereoselective Pauson-Khand reactions
- asymmetric Pauson-Khand reactions using chiral auxiliaries
- enantioselective Pauson-Khand reactions
- recent advances in catalytic Pauson-Khand reactions
- the Pauson-Khand reaction in total synthesis
- heterogenous catalytic Pauson-Khand reactions
- other carbonylative cyclizations leading to cyclopentenones
Presenting a comprehensive overview of this fundamental reaction, The Pauson-Khand Reaction will find a place on the bookshelves of any organic or organometallic chemist.
About the Author
Professor Ramon Rios Torres, Dept Química Orgànica, Universitat de Barcelona, Spain
Ramon Rios Torres was born in 1974 in Barcelona. He obtained his PhD under the supervision of Professor Albert Moyano in 2000 at the University of Barcelona, and undertook postdoctoral work with Professor P. J. Walsh at Pennsylvania University, Professor Benjamin List at Max Plank Institute, Armando Cordova at Stockholm University and Professor Alvarez-Pez at Granada, and an industrial experience at J.C. Uriach (Spain). He received an ICREA position as independent researcher in 2008 at University of Barcelona. His research interests are devoted to the discovery of new asymmetric methodologies and their applications to organic synthesis.?He is author or coauthor of more than 60 papers, 11 book chapters and 1 patent.
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