This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.
Editorial Reviews
From the Back Cover
Stem Cells Handbook, second edition, emphasizes the advances in understanding and working with embryonic and fetal stem cells as well as induced pluripotent stem cells that show the most promise for clinical use. This new edition has been completely rewritten and updated to reflect the significant advances made in this field since publication of the first edition in 2004.
The thirty-six chapters in this book – all written by recognized experts in Stem Cell research – reflect the tremendous progress in the understanding of stem cell biology and the appreciation of the potential for using stem cells for therapy of cancer, aging, injury and congenital diseases. Arguably the biggest advances have been made in obtaining different populations of stem cells, inducing mature cells to act like stem cells, and the ever-critical issue of how to get these stem cells to expand and differentiate into the tissue precursor cells that then can be used to replace lost of damaged tissues.
No less exciting are the recent advances in understanding how stem cells function to maintain tissue integrity and how to use this knowledge to prevent developmental abnormalities. Other key topics discussed include: properties of tissue stem cells , transplantation of stem cells, the stem cell as a target for cancer treatment and prevention.
About the Author
Dr. Sell is a board certified pathologist and immunologist. He began research in 1957 while a medical student at the University of Pittsburgh, in the Department of Pathology, under Frank J. Dixon. After a pathology residency at Massachusetts Hospital, and post doctoral fellowships at NIH and Birmingham England he returned to the University of Pittsburgh for 5 years before moving to the University of California at San Diego. After 12 years at UCSD, Dr. Sell took the position as Chair of Pathology and Laboratory Medicine at the University of Texas (UT) at Houston before moving to Albany Medical College. As of February 2003 he has been a senior scientist at Wadsworth Center, a Professor at University at Albany School of Public Health and an Adjunct Professor at Albany College of Pharmacy. Dr. Sell received the Rudolph L. K. Virchow Award of the Italian Medical Magazine LeadershipMedica.com for his concept of cancer stem cells; he was named Legacy Laureate of the University of Pittsburgh for his work on alpha-fetoprotein as a marker for liver cancer; and in 2007 received the Abbott Award of the International Society for Oncodevelopmental Biology and Medicine for recognizing the role of stem cells in carcinogenesis. He has published over 400 papers and 12 books, including 6 editions of Immunology, Immunopathology and Immunity. His paper with Barry Pierce (Lab. Invest. 70:6-21, 1994.) was selected as an AACR scientific landmark.
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