Stem Cell Bioprocessing: For Cellular Therapy, Diagnostics and Drug Development
Author(s): Tiago Fernandes (Author), Maria Margarida Diogo (Author), Joaquim M. S. Cabral (Author)
Publisher: Woodhead Publishing Ltd
Publication Date: 28 Feb. 2014
Edition: 1st
Language: English
Print length: 236 pages
ISBN-10: 1907568883
ISBN-13: 9781907568886
Book Description
Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed.
Key Features: maintains a unique focus on both the basic stem cell biology concepts, and their translation to large-scale bioprocessing approaches; envisages the use of stem cells in regenerative medicine and drug screening applications; discusses the application of microscale techniques as a tool to perform basic stem cell biology studies.
Contents: Characteristics of stem cells; Stem cell culture: mimicking the stem cell niche in vitro; Bioreactors for stem cell culture; Stem cell separation; Microscale technologies for stem cell culture; Stem cells and regenerative medicine; Conclusions.
Editorial Reviews
Review
“This book offers an interesting review of the current research and advances in the field of stem cell biology. It focuses on unique and complex requirements and challenges of stem cell culture and seems to target audience of stem cell researchers, but the well-written introduction to basic stem cell biology makes it accessible to a wider audience.” —Doody.com, January 3, 2014
About the Author
Dr Tiago G. Fernandes is currently a Post-doctoral research fellow at the Institute for Biotechnology and Bioengineering, Lisbon, Portugal. His research interests are focused on the development of artificial cellular niches for studying the mechanisms that affect human stem cell pluripotency, and the cellular and molecular events that regulate stem cell functions. During his doctoral studies he also worked at the Rensselaer Polytechnic Institute, NY, USA, in the development of microscale platforms for high-throughput studies of stem cell fate. Dr Maria Margarida Diogo received her PhD degree in Biotechnology from Instituto Superior Tecnico from January 2000 to April 2004. Her thesis was dedicated to the development of Bioprocesses for Production and Purification of Plasmid DNA for Gene Therapy and DNA vaccines. As a result of this work, a United States Patent was published in 2007. From April 2004 to March 2008 she received a post-doctoral fellowship to work in the field of Stem Cell Bioengineering and she is presently a Research Scientist at the Stem Cell Bioengineering Laboratory at Instituto Superior Tecnico. Dr Joaquim M. S. Cabral is Professor of Biological Engineering, in the Department of Bioengineering at Instituto Superior Tecnico (IST), Technical University of Lisbon, Portugal. He was the founder and current Head of Department of Bioengineering, and the Director of the Institute for Biotechnology and Bioengineering, a Research Laboratory Associated to the Ministry of Science, Technology and Higher Education in Portugal. His research aims at contributing to biochemical engineering science through novel developments in Bioprocess Engineering and Stem Cell Bioengineering.
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