Sequence Alignment: Methods, Models, Concepts, and Strategies
Author(s): Michael Rosenberg (Author)
Publisher: University of California Press
Publication Date: 9 Sept. 2011
Language: English
Print length: 360 pages
ISBN-10: 0520271319
ISBN-13: 9780520271319
Book Description
The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences – making sure that sequences from one source are properly compared to those from other sources – remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted. Edited by Michael S. Rosenberg with essays by many of the field’s leading experts, Sequence Alignment covers molecular causes, computational advances, approaches for assessing alignment quality, and philosophical underpinnings of the algorithms themselves.
Editorial Reviews
From the Inside Flap
“Sequence alignment represents the final frontier in the development of repeatable, comprehensive methods for phylogenetic analysis. This book will inform readers about the current status of alignment methods and will help stimulate additional work in the field.”David M. Hillis, University of Texas
“
Sequence Alignment provides an in-depth treatment of the prerequisite to many evolutionary analyses by presenting a diversity of opinions on the best way to align complex molecular sequence data. Topics covered include the basic algorithms used, global versus local procedures, the robustness alignment error detection, and a description of the programs now available. Sequence Alignment is a reassuring companion, guiding the reader through a large and complicated field.”John Huelsenbeck, Department of Integrative Biology, University of California, Berkeley
From the Back Cover
“Sequence alignment represents the final frontier in the development of repeatable, comprehensive methods for phylogenetic analysis. This book will inform readers about the current status of alignment methods and will help stimulate additional work in the field.”—David M. Hillis, University of Texas
“
Sequence Alignment provides an in-depth treatment of the prerequisite to many evolutionary analyses by presenting a diversity of opinions on the best way to align complex molecular sequence data. Topics covered include the basic algorithms used, global versus local procedures, the robustness alignment error detection, and a description of the programs now available. Sequence Alignment is a reassuring companion, guiding the reader through a large and complicated field.”—John Huelsenbeck, Department of Integrative Biology, University of California, Berkeley
About the Author
Michael S. Rosenberg is Associate Professor of Computational Evolutionary Biology and Bioinformatics in the School of Life Sciences and the Center for Evolutionary Functional Genomics of the Biodesign Institute at Arizona State University.
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