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Receptor Binding Techniques
Author(s): Mary Keen (Author)
- Publisher: Humana Press Inc.
- Publication Date: 1 Jan. 1999
- Language: English
- Print length: 400 pages
- ISBN-10: 0896035301
- ISBN-13: 9780896035300
Book Description
This cutting-edge collection of step-by-step experimental protocols demonstrates the power of radioligand binding for studying a wide variety of receptors. The methods can be applied to G protein coupled receptors, receptors with integral ion channels, and sites other than receptors, such as guanine nucleotide binding proteins, enzymes, transporters, and mRNA. The individual protocols encompass many different preparations, ranging from solubilized receptors, through membrane preparations, intact cells, and autoradiography in tissue slices, to PET and SPECT analysis of binding in living human brain. Along with the detailed, easily reproducible instructions, the protocols also address the problems inherent in the basic binding technique, such as common experimental artifacts and the definition of receptor sites, as well as problems associated with the use of particular ligands and receptor preparations. Receptor Binding Techniques shows clearly how these methods can be adapted to many different applications and fully utilized in drug discovery programs.
Editorial Reviews
Review
Research scientists who study or wish to study drug/hormone actions would benefit from this book. It is applicable for students, instructors, and advanced scientists. The editor has successfully compiled this book for the intended readers…I find this book a very useful and practical addition to the field of receptor pharmacology…This book should be open and on the bench of every student of receptor pharmacology. – Doody’s Health Sciences Book Review Journal step-by-step experimental protocols demonstrate the power of the radioligand binding an extremely useful book. – Cellular and Molecular Biology found the book easy to read and full of useful information. Having been involved in receptorology during the past 16 years, I found the content of this book comprehensive and up to date and as such the book will be useful for both the specialist as well as one just beginning in the area. – Cell Biology International …does much to dispel the mysteries surrounding the technique and provides a good many solutions to practical problems…The book is written in a uniformly accessible style and there is plenty of benefit to be derived from it for both novices and more experiences scientists wanting to learn a new technique. – Microbiology Today
From the Publisher
Excellent Review
“Research scientists who study or wish to study drug/hormone actions would benefit from this book. It is applicable for students, instructors, and advanced scientists. The editor has successfully compiled this book for the intended readers. . .I find this book a very useful and practical addition to the field of receptor pharmacology. . .This book should be open and on the bench of every student of receptor pharmacology.Doodys Health Sciences Book Review Journal
“Research scientists who study or wish to study drug/hormone actions would benefit from this book. It is applicable for students, instructors, and advanced scientists. The editor has successfully compiled this book for the intended readers. . .I find this book a very useful and practical addition to the field of receptor pharmacology. . .This book should be open and on the bench of every student of receptor pharmacology.Doodys Health Sciences Book Review Journal
