Recent Advances in Parkinsons Disease: Part II: Translational and Clinical Research (Volume 184)
Author(s): Anders Bjorklund (Editor), Angela Cenci-Nilsson
Publisher: Elsevier Science
Publication Date: December 8, 2010
Edition: 1st
Language: English
Print length: 368 pages
ISBN-10: 0444537503
ISBN-13: 9780444537508
Book Description
This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.
Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Editorial Reviews
Review
Presents Parkinson’s disease as a topic for basic, translational, and clinical investigation
From the Back Cover
This issue of Progress in Brain Research is split over two volumes and captures all the richness and complexity of Parkinson’s Disease as a topic for basic, translational, and clinical investigation. This second volume, Part II: Translational and Clinical, follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research (Section I: Animal models of PD). This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients (Section II: Exploring PD with brain imaging). Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles (Section III: Frontiers in PD treatment).
See Part I: Basic Research for sections on Genetic and molecular mechanisms of neurodegeneration in PD and Cellular and system-level pathophysiology of the basal ganglia in PD.
About the Author
As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients
Angela Cenci Nilsson (author name M. A. Cenci) is Professor of Experimental Medical Research at Lund University (Sweden) where she heads the Basal Ganglia Pathophysiology Group). The group’s research activities address the pathophysiology and pharmacology of Parkinson’s disease (PD) and L-DOPA-induced dyskinesia using a multidisciplinary and translational approach. Current projects span a large variety of topics, including synaptic dysfunctions, dopamine receptor signaling, gliovascular-neuronal interactions, and neurorestorative treatments to enhance function and plasticity in the damaged nigrostriatal pathway.
Angela has a combined clinical-basic science background, having graduated in Medicine and specialized in Neurology at the University of Verona (Italy) before obtaining a PhD degree in Neurobiology at Lund University under the supervision of Prof. Anders Björklund. In 2002 Angela received a tenured appointment as Associate Professor at Lund University, which was followed by an appointment as Full Professor in 2008.
Angela has pioneered the development of symptomatic models of parkinsonism and L-DOPA-induced dyskinesia in rodents, and exploited these models to discover cellular mechanisms of disease and new therapeutic approaches. For these research achievements, she has received several awards (such as, the Erik K. Fernström Award for Young Promising Investigators, the Medal of Honours for Parkinson´s Research by the Swedish Parkinson’s Disease Foundation, and a recent membership in the Royal Academy for the Natural Sciences, Medicine and Technology in Lund). Angela currently serves on the scientific advisory boards and steering committees of several national and international research organizations, including the Swedish National Microscopy Infrastructure, The Swedish Parkinson’s Research Foundation, the Swedish Brain Foundation, the International Association for Parkinsonism and Related Disorders (IAPDR), and the International Basal Ganglia Society (IBAGS).
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