Precision Medicine, AI and the Science of Personalized Healthcare

Precision Medicine, AI and the Science of Personalized Healthcare book cover

Precision Medicine, AI and the Science of Personalized Healthcare

Author(s): James Wallace (Author)

  • Publisher: Wiley
  • Publication Date: September 30, 2025
  • Edition: 1st
  • Language: English
  • Print length: 352 pages
  • ISBN-10: 139434158X
  • ISBN-13: 9781394341580

Book Description

A fascinating combination of patient stories and scientific explanation shedding light on the most promising trend in healthcare today: precision medicine
 
In
Precision Medicine, AI and the Science of Personalized Healthcare, Harvard Business School senior researcher and former DecisionRx CEO James Wallace delivers an eye-opening new discussion of how cutting-edge precision medicine is transforming the cost, access, and outcomes of modern healthcare. The author relies on real-world experiences that showcase the practical, human benefits of precision medicine and how those benefits can accrue to people from all walks of life.
 
You’ll discover how personalized treatments―those based on a patient’s genetic, environmental, and lifestyle attributes―can do more than traditional medicine to combat a wide variety of genetic disorders, chronic illnesses, and treatment inefficiencies. You’ll also learn about precision medicine’s potential to lower healthcare costs for everyone while improving outcomes.
 
Inside the book:
 

  • Explorations of how precision medicine can address the triple crisis of cost, access, and quality that currently plagues the US healthcare system
  • Unique combinations of compelling human stories and accessible scientific explanations that render a complex subject approachable and relatable
  • A compelling argument for how the precision medicine movement can transform the healthcare system and the lives of the people who navigate it every day

 
Perfect for healthcare, technology, and business professionals grappling with the skyrocketing costs of patient care,
Precision Medicine, AI and the Science of Personalized Healthcare is also a must-read for healthcare consumers frustrated by the current, “one-size-fits-all” approach to medicine.

Editorial Reviews

Review

Praise for Precision Medicine, AI and the Science of Personalized Healthcare:

“I have had the great pleasure and joy of working with Jim Wallace for many years. He is the living embodiment of the ‘Do good and do well’ innovation ethic so much needed in healthcare.”
—Regina Herzlinger, Nancy R. McPherson Professor of Business Administration, Harvard Business School

“Medicine, like warfare, is leveraging information and technology to change not only it’s superficial appearance, but also the fundamental dynamics that drive it. Jim Wallace’s entertainingly informative Precision Medicine, Al and the Science of Personalized Healthcare is a tremendous guidebook to the rapidly arriving new reality within our grasp. A fascinating, important read.”
—Stanley McChrystal, General (Ret.), U.S. Army and CEO, McChrystal Group

“Jim has always had a unique ability to see around the corner. In Precision Medicine, he connects the dots between Big Data, AI, and the most important stakeholder—the patient. This book is a timely and insightful contribution from a leader who’s lived at the intersection of innovation and care.”
—Leonard Schlesinger, Baker Foundation Professor, Harvard Business School

“Jim Wallace brings the science of precision medicine to life with the same integrity and clarity he brings to his research at Harvard Business School. This book is more than a compelling argument for healthcare transformation—it’s a deeply human look at how AI and personalization can actually deliver better care for real people.”
—John Driscoll, former CEO, CareCentrix and President, Walgreens U.S. Healthcare

“Jim Wallace’s book brings precision medicine to life through powerful, real-world examples. I was especially struck by the stories of patients Michael and Jennifer, Emily, Amy, and Susan—they’re a practical, relatable look at how AI, wearables, and genomics can transform care. Precision Medicine isn’t just theory—it’s a guide to what’s possible today.”
—John D. Couris, President and CEO, Florida Health Science Center-Tampa General Hospital

“Clear, well-researched, and clinically relevant—this book shows how pharmacogenomics and medication optimization can deliver on the promise of safer, more effective treatments.”
—Yoona Kim, CEO, Arine

Precision Medicine: AI and the Science of Personalized Healthcare offers a compelling vision for the future of patient-centered care. James Wallace masterfully synthesizes today’s most important clinical innovations, from pharmacogenomics and digital biomarkers to AI-driven diagnostics and predictive analytics, into a readable, deeply human narrative. A must-read for clinicians, executives, and health policy leaders—Wallace has provided the roadmap. Now it’s the job of clinician executives to implement!”
—Steven Goldberg MD, Chief Medical Officer, HealthTrackRx

From the Author

We are living in the age that Alvin Toffler called Future Shock—a time when information moves faster than the systems built to serve us. Nowhere is that more painfully obvious than in healthcare.
 
This book was born out of a simple but urgent question:
How do we turn the overwhelming data now available—wearables, genomics, lifestyle and environmental information—into something truly useful for the individual? Precision medicine is the answer, but not in the buzzword sense. It’s the re-centering of care around the patient—one person, one body, one decision at a time.
 
I wrote this book to help make sense of a fragmented system, to show how Big Data and artificial intelligence can become not just tools for efficiency, but catalysts for understanding. When integrated wisely, they don’t just make medicine smarter—they make it personal.
 
This is not a book about technology for its own sake. It’s about a future of healthcare that is proactive, individualized, and empowering. A future that’s already arriving.
 
Let’s follow it.

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