Ocular Transporters and Receptors: Their Role in Drug Delivery
Author(s): Ashim K. Mitra (Author, Editor)
Publisher: Woodhead Publishing Ltd
Publication Date: 23 Oct. 2013
Edition: 1st
Language: English
Print length: 276 pages
ISBN-10: 1907568867
ISBN-13: 9781907568862
Book Description
Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.
Key Features: highly focused on ocular transporters; most up-to-date research compilation; detailed description of role of transporters and receptors in ocular drug discovery and delivery; discussion on transporter-metabolism interplay in the eye and its potential role in drug delivery and drug interactions; role of intracellular organelles in ocular drug delivery.
Editorial Reviews
Review
“This is an excellent reference for researchers and scientists interested in ocular drug delivery…It is often a challenge to improve the bioavailability of drugs in various parts of the eye. Successful receptor targeting enhances bioavailability, and this book provides a framework for further research in ocular receptor targeting with the aim of improving bioavailability.” Rating: 2 Stars —Doody.com, January 17, 2014
About the Author
Dr. Ashim K. Mitra is currently Vice Provost for Interdisciplinary Research at the University of Missouri, Kansas City. He is also the University of Missouri Curators Professor of Pharmacy, Chairman of the Division of Pharmaceutical Sciences, and Co-Director of the School of Medicine s Vision Research Centre. He has over 30 years of experience in the field of ocular drug delivery and disposition. Current studies include mechanisms of transscleral permeation of both small and large molecules, and the design of new biopolymers for long-term topical and subconjunctival administrations. Dr. Mitra has served as a regular member of the National Institute of Health (NIH) Pharmacology & Toxicology Study Section and on the NIH Gene and Drug Delivery Study Section. He authored and co-authored over 300 refereed articles, editor of 6 books, 60 book chapters in the area of formulation development and ocular drug delivery, awarded 9 patents, and presented (along with his research group) well over 500 presentations/abstracts at national and international scientific meetings. He is a recipient of a numbers of research awards from NIH, AAPS, AACP, and numerous pharmaceutical organizations.
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