Nitroxides: Applications in Chemistry, Biomedicine, and Materials Science
Author(s): Gertz I. Likhtenshtein (Author), Jun Yamauchi (Author), Shin'ichi Nakatsuji (Author), Alex I. Smirnov (Author), Rui Tamura (Author)
Publisher: Wiley-VCH
Publication Date: 20 Feb. 2008
Edition: 1st
Language: English
Print length: 438 pages
ISBN-10: 3527318895
ISBN-13: 9783527318896
Book Description
Covering all aspects of this field, this volume also critically discusses recent results obtained with the use of nitroxides, while providing an analysis of future developments. Written by a group of scientists with long-term experience in investigating the chemistry, physicochemistry, biochemistry and biophysics of nitroxides, the book is not intended as an exhaustive survey of each topic, but rather a discussion of their theoretical and experimental background, as well as recent advances. The first four chapters expound the general theoretical and experimental background and the advantages of modern ESR technique. Chapter 5 focuses on fundamentals and recent results in the preparation and basic chemical properties, while the next two chapters briefly outline principles and current results in nitroxides as spin probes, and as redox probes and spin traps. These chapters form the basis for the subsequent more detailed studies of nitroxides in physicochemistry, while the final chapters concentrate on the advantages of magnetic materials on the basis of nitroxides. Finally, the concluding chapter considers the rapidly developing field of biomedical, therapeutic and clinical applications. With more than 1,100 references to essential literature, this volume provides fundamental knowledge of instrumentation, data interpretation, capacity and recent advantages of nitroxide applications, allowing readers to understand how nitroxides can help them in solving their own problems.
Editorial Reviews
Review
“This book provides a one-stop resource of useful information dealing with the synthesis and properties of nitroxides.” (Angewandte Chemie International Edition, December 2008)
From the Inside Flap
The main objective of this volume is to provide readers with comprehensive discussions of recent results obtained in the field of nitroxides and related compounds and to present readers with in-depth analysis of avenues for future developments in this growing area. Written by a group of long-proven experts in chemistry, physical chemistry, biochemistry and biophysics of nitroxides, this book lays out theoretical and experimental basis and applies it to a variety of practical examples in these diverse but interrelated fields. The first four chapters expound the general theoretical and experimental essentials of nitroxide bulk magnetic and magnetic resonance properties as well as advantages of modern ESR techniques. Chapter 5 focuses on fundamentals and recent results in chemical synthesis and basic chemical properties of nitroxides, while the following two chapters briefly outline the principles and current results in employing these compounds for investigating molecular structure and dynamics, and as redox probes and spin traps. These chapters form the basis for subsequent and more detailed discussion of molecular property studies of various paramagnetic metal systems. The following chapters concentrate on advantages of designing and investigating magnetic materials on the basis of nitroxides as well as reviewing recent spin labeling results in studies of molecular structure, dynamics and functional activity of proteins, enzymes, biomembranes, nucleic acids, and polysaccharides. Finally, concluding chapter considers rapidly developing fields of biomedical, therapeutic and clinical applications of nitroxides. With numerous references to essential literature, this volume provides chemical, biochemical, biomedical and materials science researchers with a tool to rapidly gain fundamental knowledge in instrumentation, data interpretation, capacity and recent advantages of nitroxide applications, and take them to the level of employing nitroxide in their research fields on their own. The book is equally suitable as a subsidiary text for instructors, and graduate and undergraduate students in biochemical and chemical departments.
From the Back Cover
The main objective of this volume is to provide readers with comprehensive discussions of recent results obtained in the field of nitroxides and related compounds and to present readers with in-depth analysis of avenues for future developments in this growing area. Written by a group of long-proven experts in chemistry, physical chemistry, biochemistry and biophysics of nitroxides, this book lays out theoretical and experimental basis and applies it to a variety of practical examples in these diverse but interrelated fields. The first four chapters expound the general theoretical and experimental essentials of nitroxide bulk magnetic and magnetic resonance properties as well as advantages of modern ESR techniques. Chapter 5 focuses on fundamentals and recent results in chemical synthesis and basic chemical properties of nitroxides, while the following two chapters briefly outline the principles and current results in employing these compounds for investigating molecular structure and dynamics, and as redox probes and spin traps. These chapters form the basis for subsequent and more detailed discussion of molecular property studies of various paramagnetic metal systems. The following chapters concentrate on advantages of designing and investigating magnetic materials on the basis of nitroxides as well as reviewing recent spin labeling results in studies of molecular structure, dynamics and functional activity of proteins, enzymes, biomembranes, nucleic acids, and polysaccharides. Finally, concluding chapter considers rapidly developing fields of biomedical, therapeutic and clinical applications of nitroxides. With numerous references to essential literature, this volume provides chemical, biochemical, biomedical and materials science researchers with a tool to rapidly gain fundamental knowledge in instrumentation, data interpretation, capacity and recent advantages of nitroxide applications, and take them to the level of employing nitroxide in their research fields on their own. The book is equally suitable as a subsidiary text for instructors, and graduate and undergraduate students in biochemical and chemical departments.
About the Author
Gertz Likhtenshtein has been full Professor at the Ben-Gurion University of Negev (Israel) and emerited 2003. Among his many awards are the Medal of the Exhibition of Economic Achievement, the Diploma of Discovery, the USSR State Price and the Diploma of the Israel Chemical Society. He is a member of the International ESR Society, the American Biophysical Society, the Israel Chemical Society and the Israel ESR Society.
Jun Yamauchi has emerited as full Professor from Kyoto University in 2006. He is a member of the Chemical Society of Japan, and the Society of Electron Spin Science and Technology.
Shin´ichi Nakatsuji is Professor of Organic and Materials Chemistry at the University of Hyogo. His major research topics are novel electron systems, Dye chemistry, organic magnetic materials and organic conductors. He is a member of the GDCh, ACS, and Chemical Society of Japan.
Rui Tamura is Professor at Kyoto University. His research areas include structural organic chemistry, physical organic chemistry and environmental chemistry, i.e. synthesis and reaction of nitro compounds and nitroxides.
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