Nanoparticulate drug delivery highlights and examines the transition of nanoparticulate drug delivery systems, operating at scales of billionths of a metre, from laboratory into a commercially viable sector. This has been a challenging journey, beginning in 2005 with the introduction of Abraxane, the first nanotechnology-based drug delivery product for the treatment of breast cancer, which marked the advent of nanotechnology in the pharmaceutical and healthcare industry. The book describes the need for various types of nanoparticulate drug delivery systems in different application areas, and assesses the challenges associated with their advance to society.
Key Features: discusses the issues surrounding nanoparticulate products, based on personal experience of their formulation; provides an overview of new application areas, including RNA interference; outlines the pros and cons of nanoparticulate products, and discusses how these may influence their route into the commercial sector; provides information relevant to both the industrial and the academic sectors.
Contents: Nanoparticulate systems as drug carriers: The need; Nanoparticles as drug carriers; Characterization techniques for nanoparticulate carriers; Nanotoxicology: Evaluating toxicity potential of drug-nanoparticles; Regulatory aspects of nanoparticulate drug delivery systems; Clinical trials and industrial aspects; Case studies: Nano-systems in the market.
Editorial Reviews
About the Author
Vandana Patravale is a Professor of Pharmaceutics at the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India. Her research group is actively involved in the design and development of colloidal drug delivery systems for various routes including oral, topical, transdermal, nasal and parenteral. Prajakta Dandekar is the first female Indian scientist to be award the European Respiratory Society – Marie Curie Joint Postdoctoral Fellowship and is currently a guest scientist at the Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany. Her research interests include the design of polymeric nanoparticles of novel polymers for application in siRNA delivery and gene therapy Ratnesh Jain has been awarded the Alexander von Humboldt Postdoctoral Fellowship by the AvH Foundation and is currently a guest scientist at the Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany. His research interests include design of nanoparticles of commercial cationic polymers for application in siRNA delivery and gene therapy.
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