Wow! eBook
mTOR Signaling in Ophthalmology: Understanding the Essentials
Author(s): Kambiz Thomas Moazed (Author)
- Publisher: Springer
- Publication Date: September 5, 2025
- Language: English
- Print length: 462 pages
- ISBN-10: 303205043X
- ISBN-13: 9783032050434
Book Description
The mammalian target of rapamycin (mTOR) is a central node in cell regulation, impacting everything from cellular growth and metabolism to the intricate mechanisms of aging and disease. Its role in the eye, however, is an emerging field that promises to revolutionize our understanding of ocular health and disease.
This book discusses the role of mTOR signaling in the eye. It aims bridge the gap between deep molecular biology and clinical ophthalmology by focusing on the profound effects of mTOR signaling in various parts of the eye. The initial chapters of this book lay the foundational knowledge necessary to understand the complex biology of mTOR, followed by the specific effects on each individual parts of the eye.
This book is written for researchers, clinicians, and students who are part of a multidisciplinary team striving to push the boundaries of ocular research into mTOR pathways. By the end of this journey, readers will have a comprehensive understanding of the multifaceted roles of mTOR in the eye and the brain, equipped with the knowledge to translate these insights into innovative treatments for ocular and neurodegenerative diseases.
Editorial Reviews
From the Back Cover
Recent advances in research have identified the mTOR signaling pathway as a promising therapeutic target for numerous ocular diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, and more. These conditions share common pathological features, such as oxidative stress, which leads to damage of key retinal cells like photoreceptors, retinal ganglion cells (RGCs), and retinal pigment epithelium (RPE). The mTOR pathway plays a crucial role in regulating oxidative stress but is also influenced by reactive oxygen species (ROS). Understanding this intricate relationship is essential for developing new treatments for retinal degeneration.
This book emphasizes the role of mTOR-mediated autophagy (recycling) in the pathogenesis of many of these diseases, with a particular focus on the therapeutic potential of rapamycin, an mTOR inhibitor, across various ocular conditions. With extensive insights from both basic and clinical research, the book explores the potential of mTORC1 inhibition for example in slowing myopia progression, as well as rapamycin’s application in conditions like Graves ophthalmopathy, dry eye, uveitis, Sjogren’s syndrome, geographic atrophy, and ocular solid tumors.
For the first time, this book compiles key findings on the influence of mTOR signaling in ocular diseases, making it an invaluable resource for researchers, medical professionals, students, and those in the ophthalmology industry. It provides a comprehensive overview of the therapeutic potential of targeting mTOR in eye diseases, offering critical insights into the ongoing research and future clinical applications.
About the Author
Dr. Kambiz Thomas Moazed, MD, is a board certified ophthalmologist with over 40 years of surgical experience in NYC. At present he is an active surgical attending at Manhattan Eye and Ear and Throat Hospital of Lenox Hill. After graduation from medical school, Dr. Moazed completed a year of research fellowship in eye pathology at Stanford University’s Department of Ophthalmology. He then completed a year of residency in general surgery at the Stanford Medical Center. He then followed his interest in Ophthalmology and completed another year of fellowship in eye pathology at Harvard Medical School’s Massachusetts Eye and Ear Infirmary under Dr. Daniel Albert. He completed his Ophthalmology residency program at Harvard in 1982.
Dr. Moazed became affiliated with Columbia University in New York City, where he served as Associate Clinical Professor, teaching residents at the St. Luke’s Roosevelt Hospital Centers for 25 years. He also served as the Director of Oculo-Plastic Surgery and Orbital Surgery at Harlem Hospital under the Columbia University affiliation for 15 years.
