DNA Methylation and Complex Human Disease

This book describes the modifications of DNA methylation in various major human disease groups, including nonneoplastic diseases that could provide a rationale to develop novel therapeutic strategies such as the use of DNA methylation as a potential tool for determining cancer risk.

In DNA Methylation in Complex Human Disease, expert authors review the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including therapies and the possibility of using methyl donors. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis. The authors also present the importance of high-throughput methylome analysis, as well as the advantages of DNA methylation as a biomarker over other molecular processes. DNA Methylation in Complex Human Disease is an excellent resource for basic biology and translational researchers interested in developmental biology, genetics health genomics, epigenesist in complex disease, and therapeutic possibilities, and developmental biologists, geneticists, biotechnologists, and epidemiologists have much to gain from this specialized and focused volume.