Methods for Studying Nucleic Acid/Drug Interactions

Methods for Studying Nucleic Acid/Drug Interactions book cover

Methods for Studying Nucleic Acid/Drug Interactions

Author(s): Meni Wanunu (Editor), Yitzhak Tor

  • Publisher: CRC Press
  • Publication Date: 21 Nov. 2018
  • Edition: 1st
  • Language: English
  • Print length: 408 pages
  • ISBN-10: 1138382035
  • ISBN-13: 9781138382039

Book Description

Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the efficacy and nature of interactions between nucleic acids and their putative ligands. This progress can benefit tremendously from new methods that probe nucleic acid/ligand interactions both rapidly and quantitatively.

A variety of novel methods for these studies have emerged in recent years, and Methods for Studying DNA/Drug Interactions highlights new and non-conventional methods for exploring nucleic acid/ligand interactions. Designed to present drug-developing companies with a survey of possible future techniques, the book compares their drawbacks and advantages with respect to commonly used tools. Perhaps more importantly, this book was written to inspire young scientists to continue to advance these methods into fruition, especially in light of current capabilities for assay miniaturization and enhanced sensitivity using microfluidics and nanomaterials.

Editorial Reviews

Review

“By focusing on a selection of novel and emerging techniques, Wanunu and Tor provide a remarkable overview of biophysical and computational advances in structure-based investigations of the interactions between nucleic acids and small-molecule ligands. An impressive collection of approaches is described: analytical biophysical techniques alongside novel exploitation of chemical and computational tools. Indeed, the smart combination of results obtained by classical methods with state of the art biophysical approaches reveals astonishing insights, thus paving new research avenues in this central area of research.”
―Prof. Ada Yonath, Weizmann Institute of Science, 2009 Nobel Laureate in Chemistry

From the Back Cover

This book describes emerging, non-conventional methods for probing the interactions of small molecules with nucleic acids as well as modern computational methods for assessment. By highlighting novel methods for nucleic acid/ligand interactions, the text presents drug developing companies with a survey of possible future techniques as well as their drawbacks and advantages with respect to common techniques. In addition, and perhaps more importantly, this book is designed to inspire young scientists to continue and advance these methods into fruition, especially in light of current capabilities for assay miniaturization and enhanced sensitivity using microfluidics and nanomaterials.

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