Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts
Author(s): Janine Cossy (Editor), Stellios Arseniyadis (Editor), Christophe Meyer (Editor), Robert H. Grubbs (Foreword)
Publisher: Wiley-VCH
Publication Date: 19 May 2010
Edition: 1st
Language: English
Print length: 412 pages
ISBN-10: 3527324402
ISBN-13: 9783527324408
Book Description
Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this is a comprehensive view of a hot topic. Written by top international authors, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. A real must-have for anyone working in natural product synthesis.
Editorial Reviews
From the Inside Flap
The tremendous success of the so-called metathesis reaction during the last decade (Nobel prize 2005) is reflected in its huge impact on natural product synthesis and related fields. A very significant portion of contemporary total syntheses comprises at least one metathetic conversion; while many of them rely on metathesis as the key strategic element. Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications.
From the contents: * Synthesis of natural products containing medium-size carbocycles, macrocycles, oxygen and nitrogen heterocycles by ring-closing alkene metathesis * Phosphorus and sulfur heterocycles * Tethered ring-closing metathesis * Metathesis involving a relay and applications in natural products synthesis * Ene-yne metathesis * Ring-closing alkyne metathesis * Cross, cascade and asymmetric metathesis * Solid-phase metathesis reactions
Written by top international authors, this is a real must-have for anyone working in natural product synthesis.
From the Back Cover
The tremendous success of the so-called metathesis reaction during the last decade (Nobel prize 2005) is reflected in its huge impact on natural product synthesis and related fields. A very significant portion of contemporary total syntheses comprises at least one metathetic conversion; while many of them rely on metathesis as the key strategic element. Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications.
From the contents: * Synthesis of natural products containing medium-size carbocycles, macrocycles, oxygen and nitrogen heterocycles by ring-closing alkene metathesis * Phosphorus and sulfur heterocycles * Tethered ring-closing metathesis * Metathesis involving a relay and applications in natural products synthesis * Ene-yne metathesis * Ring-closing alkyne metathesis * Cross, cascade and asymmetric metathesis * Solid-phase metathesis reactions
Written by top international authors, this is a real must-have for anyone working in natural product synthesis.
About the Author
Janine Cossy graduated from the University of Reims. After a postdoctoral stay with Barry Trost (1980-1982) at the University of Wisconsin, she returned to Reims where she became Director of Research of the CNRS in 1990. In the same year she moved to Paris to become Professor of Organic Chemistry at the ESPCI (Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris). She has published more than 330 articles and 12 patents in the field of synthetic organic chemistry and natural product synthesis. She is Associate Editor at Organic Letters since 2005.
Stellios Arseniyadis completed his PhD in 2002 under the guidance of Dr. C. Mioskowski at the Universite Louis Pasteur (Strasbourg, France). He then joined the Research & Innovation team at Rhodia Chirex (Boston, USA) to work on the development of palladium-catalyzed coupling reactions. In 2003, he began a postdoc with Professor A.C. Spivey at Imperial College (London, UK) and, in 2004, joined Professor K.C. Nicolaou?s group at The Scripps Research Institute (La Jolla, USA). In 2005, he was appointed a permanent CNRS researcher position in the group of Professor Cossy. His research interests include the development of new methods in the field of asymmetric catalysis and their application to the total synthesis of natural products.
Christophe Meyer graduated from the Ecole Nationale Superieure de Chimie de Paris in 1991 and received his PhD from University Pierre et Marie Curie (Paris) in 1994 under the supervision of Professor J.-F. Normant and Doctor I. Marek. After a postdoctoral stay at the University of Toronto (Canada) in the laboratory of Professor M. Lautens, he was appointed a CNRS researcher position in 1996 in the group of Professor J. Cossy (ESPCI) and became Director of Research in 2008. His research focuses on the development of synthetic methodologies and total synthesis of natural products.
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