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Hydrogels in Cell-Based Therapies: Rsc: Volume 2
Author(s): Che J. Connon (Editor), Ian W. Hamley (Editor), William L. Murphy (Contributor), Bing Xu (Contributor), Sarah Heilshorn (Contributor), Roanne Jones (Contributor), Vitaliy Khutoryanskiy (Contributor), Rein Ulijn (Contributor), Bernice Wright (Contributor), Ian W Hamley (Series Editor)
- Publisher: Royal Society of Chemistry
- Publication Date: 18 Mar. 2014
- Edition: Illustrated
- Language: English
- Print length: 238 pages
- ISBN-10: 1849737983
- ISBN-13: 9781849737982
Book Description
Leading experts provide a comprehensive overview of recent progress in the synthesis of different hydrogels and their biomedical applications.
Editorial Reviews
Review
From the Back Cover
Hydrogels are attractive materials for uses in regenerative medicine due to their biocompatibility and high water absorbance and retention properties. Applications are emerging in stem cell niches, biopolymers and synthetic polymers for tissue scaffolding, wound healing and hydrogels for cellular diagnostics and delivery.
Hydrogels in Cell-Based Therapies looks at the use of different polymers and other bionanomaterials to fabricate different hydrogel systems and their biomedical applications including enzyme responsive hydrogels and biomaterials, thermally responsive hydrogels, collagen gels and alginates.
With complementary expertise in cell biology and soft materials, the Editors provide a comprehensive overview of recent updates in this highly topical field. This highly interdisciplinary subject will appeal to researchers in cell biology, biochemistry, biomaterials and polymer science and those interested in hydrogel applications.
About the Author
Ian W. Hamley is Diamond Professor of Physical Chemistry at the University of Reading, UK and holds a Royal Society-Wolfson Research Merit Award. He has previously authored three books on soft matter and block copolymers and edited two texts. His research interests are focussed on soft materials including polymers, colloids and biomaterials.
Che Connon is Reader in Tissue Engineering and Cell Therapy. His research focus is primarily in the area of corneal tissue engineering, seeking to engineer functional replacement and temporary 'bridge' tissues while also developing model systems to study physiological and pathophysiological corneal tissue formation.
Excerpt. © Reprinted by permission. All rights reserved.
Hydrogels in Cell-Based Therapies
By Che J. Connon, Ian W. Hamley
The Royal Society of Chemistry
Copyright © 2014 The Royal Society of Chemistry
All rights reserved.
ISBN: 978-1-84973-798-2
Contents
Chapter 1 Soluble Molecule Transport Within Synthetic Hydrogels in Comparison to the Native Extracellular Matrix Matthew Parlato and William Murphy,
Chapter 2 Biocompatibility of Hydrogelators Based on Small Peptide Derivatives Yi Kuang, Ning Zhou, and Bing Xu,
Chapter 3 Recombinant Protein Hydrogels for Cell Injection and Transplantation Patrick L. Benitez and Sarah C. Heilshorn,
Chapter 4 The Instructive Role of Biomaterials in Cell-Based Therapy and Tissue Engineering Roanne R. Jones, Ian W. Hamley, and Che J. Connon,
Chapter 5 Microencapsulation of Probiotic Bacteria into Alginate Hydrogels M. T. Cook, D. Charalampopoulos, and V. V. Khutoryanskiy,
Chapter 6 Enzyme-Responsive Hydrogels for Biomedical Applications Yousef M. Abul-Haija and Rein V. Ulijn,
Chapter 7 Alginate Hydrogels for the 3D Culture and Therapeutic Delivery of Cells Bernice Wright and Che J. Connon,
Chapter 8 Mechanical Characterization of Hydrogels and its Implications for Cellular Activities Samantha L. Wilson, Mark Ahearne, Alicia J. El Haj, and Ying Yang,
Chapter 9 Extracellular Matrix-Like Hydrogels for Applications in Regenerative Medicine Aleksander Skardal,
Subject Index,
CHAPTER 1
Soluble Molecule Transport Within Synthetic Hydrogels in Comparison to the Native Extracellular Matrix
MATTHEW PARLATO AND WILLIAM MURPHY
1.1 Introduction
Soluble factor signalling and gradient formation are of known biological importance and direct processes such as stem cell differentiation, cellular migration, limb bud development, and neural tube development. Soluble transport within the in vivo environment is complex, involving spatiotemporal interactions and molecular recognition between soluble molecules and extracellular matrix (ECM) components. Because of such complexity, what is known and what can be studied about soluble transport in vivo is limited. Therefore, the use of well-defined in vitro experimental platforms is an attractive option. Because of the similarity of hydrogels to the native ECM, synthetic hydrogels can serve as model systems for the study of soluble transport and gradient formation within the ECM. Synthetic hydrogels are also useful because of their biocompatibility and adaptability for use with a variety of chemistries.
The hydrated polymer chains of synthetic hydrogels slow solute movement just as the macromolecules within the ECM do, thus assisting in the formation of concentration gradients. Furthermore, drug delivery technologies have been incorporated into synthetic hydrogels that serve as well-defined soluble factor sources and sinks within the hydrogel. Other experimental approaches seek to incorporate the ability of the native ECM to specifically bind and release soluble molecules into synthetic hydrogels by the incorporation of proteoglycans or peptides that have high binding affinities for specific soluble molecules. Many methods also exist that exert temporal control over transport within synthetic hydrogels by allowing the hydrogel to degrade over time, be remodelled by cell-secreted enzymes, or respond to external cues such as temperature or pH.
There are many articles and reviews that discuss the first principles of transport within the native ECM and synthetic hydrogels separately; however, the purpose of this chapter is to compare and contrast the two. We endeavour to address some of the cr
