The theory, methods, and practices needed to generate and screen very large, high-quality, small molecule, and DNA-encoded libraries
Describing the development and practice of DNA-encoded library synthesis technology, this book expertly details an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery, and fragment-based screening. A Handbook for DNA-Encoded Chemistry is comprised of chapters summarizing practical methods, theoretical analysis, and reported applications. Important aspects of this technology, including DNA-compatible chemistry, DNA-encoded library synthesis, design of "chemical genes," analytical methods for small molecule-DNA libraries, selection methods, hit identification, and DNA-directed chemistry are explored.
This book offers practicing chemists a variety of benefits:
- Guidance for understanding and applying DNA-encoded combinatorial chemistry to generate and screen novel chemical libraries
- A bridge to the interdisciplinary areas of DNA-encoded combinatorial chemistry synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
- Instruction for medicinal and pharmaceutical chemists to efficiently broaden available "chemical space" for drug discovery
- Expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Despite many publications from laboratories specializing in DNA-encoded chemistry published since 1992, there has been no technical handbook offering this level of detail.
From the Back Cover
The theory, methods, and practices needed to generate and screen very large, high-quality, small molecule, and DNA-encoded libraries
Describing the development and practice of DNA-encoded library synthesis technology, this book expertly details an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery, and fragment-based screening. A Handbook for DNA-Encoded Chemistry is comprised of chapters summarizing practical methods, theoretical analysis, and reported applications. Important aspects of this technology, including DNA-compatible chemistry, DNA-encoded library synthesis, design of "chemical genes," analytical methods for small molecule-DNA libraries, selection methods, hit identification, and DNA-directed chemistry are explored.
This book offers practicing chemists a variety of benefits:
- Guidance for understanding and applying DNA-encoded combinatorial chemistry to generate and screen novel chemical libraries
- A bridge to the interdisciplinary areas of DNA-encoded combinatorial chemistry synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
- Instruction for medicinal and pharmaceutical chemists to efficiently broaden available "chemical space" for drug discovery
- Expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Despite many publications from laboratories specializing in DNA-encoded chemistry published since 1992, there has been no technical handbook offering this level of detail.
About the Author
ROBERT A. GOODNOW, JR. is the Executive Director of the Chemistry Innovation Centre, Discovery Sciences at AstraZeneca and the Founder of GoodChem Consulting, LLC. He has extensive experience in drug discovery and chemistry technologies including carbohydrate, combinatorial, oligonucleotide, and analytical chemistry. Robert Goodnow has authored or coauthored nearly 100 publications and patents and has spoken extensively on the topics of drug lead finding and the outsourcing of drug discovery chemistry. He has lectured as an adjunct professor of medicinal chemistry.
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