Author(s): Derek J. Chadwick (Editor), Jamie A. Goode
Publisher: Wiley
Publication Date: 1 Feb. 2008
Edition: 1st
Language: English
Print length: 258 pages
ISBN-10: 0470516046
ISBN-13: 9780470516041
Book Description
The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that neuregulin 1 (NRG1)is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development of the cardiovascular and nervous systems. Lack of NRG1 function may be involved in dysregulation of synaptogenesis and synaptic plasticity in the adult mediated through glutamate receptor function. Polymorphisms for BDNF (brain-derived neurotrophic factor) have also been implicated in the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic factor that plays an important role in the pathophysiology of depression, bipolar disease and other psychiatric disorders. Other topics addressed in this book include neuroplasticity and neurotrophic factors, signal transduction by neurotrophins, intracellular trafficking of growth factors, trophic factors and cognitive functions, neurotrophins and depression, and pharmacological treatments of schizophrenia.
Editorial Reviews
From the Inside Flap
Novartis Foundation Symposium 289
Growth factors and psychiatric disorders
Chair: Moses V. Chao
Psychiatric disorders such as depression, bipolar disease and schizophrenia are debilitating illnesses that are influenced by many genetic and environmental factors. While little is known about the neural circuits that underlie such disorders, the convergence of psychiatric, genetic and basic neuroscience research is providing new and exciting insights.
In recent years genetic studies have identified several growth factors as susceptibility genes for depression, schizophrenia, and learning and memory. This suggests that psychiatric disorders may be influenced by a small number of genes with multiple actions. These genes will provide clues to the biochemical mechanisms and pathways that underlie these complex disorders.
This is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findings and look at future directions.
Topics addressed include
Neuroplasticity and neurotrophic factors.
Mechanisms of intracellular trafficking of growth factors.
BDNF gene variants in affective disorders.
Trophic factors and cognitive functions.
Neurotrophins and depression.
Schizophrenia genes and neuropathology.
Pharmacological treatments of schizophrenia.
Growth factors and psychiatric disorders will be of particular interest to psychiatrists, neurologists and geneticists, as well as cell and molecular biologists, and neuroscientists.
From the Back Cover
Novartis Foundation Symposium 289
Growth factors and psychiatric disorders
Chair: Moses V. Chao
Psychiatric disorders such as depression, bipolar disease and schizophrenia are debilitating illnesses that are influenced by many genetic and environmental factors. While little is known about the neural circuits that underlie such disorders, the convergence of psychiatric, genetic and basic neuroscience research is providing new and exciting insights.
In recent years genetic studies have identified several growth factors as susceptibility genes for depression, schizophrenia, and learning and memory. This suggests that psychiatric disorders may be influenced by a small number of genes with multiple actions. These genes will provide clues to the biochemical mechanisms and pathways that underlie these complex disorders.
This is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findings and look at future directions.
Topics addressed include
Neuroplasticity and neurotrophic factors.
Mechanisms of intracellular trafficking of growth factors.
BDNF gene variants in affective disorders.
Trophic factors and cognitive functions.
Neurotrophins and depression.
Schizophrenia genes and neuropathology.
Pharmacological treatments of schizophrenia.
Growth factors and psychiatric disorders will be of particular interest to psychiatrists, neurologists and geneticists, as well as cell and molecular biologists, and neuroscientists.
About the Author
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: MOSES V CHAO, Skirball Institute of Biomolecular Medicine, New York, USA
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