Name: Glycolysis: Tissue-Specific Metabolic Regulation in Physio-pathological Conditions
Author: Ferreira
ISBN: 9780323917049

Glycolysis: Tissue-Specific Metabolic Regulation in Physio-pathological Conditions book cover

Glycolysis: Tissue-Specific Metabolic Regulation in Physio-pathological Conditions

Author(s): Ferreira

Publisher: Academic Press
Publication Date: 13 Oct. 2023
Edition: 1st
Language: English
Print length: 490 pages
ISBN-10: 0323917046
ISBN-13: 9780323917049

Book Description

Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.

Features chapter contributions from international leaders in the field
Spans fundamental aspects of glycolysis, patho-physiology and drug discovery
Includes step-by-step instruction in a range of research protocols, ranging from Omics to interactive analysis and measuring glycolysis flux

Editorial Reviews

Review

Offers a deep, interdisciplinary discussion of glycolysis and its role in tissue-specific diseases, addressing basic biochemistry, patho-physiology, drug discovery and research methods

From the Back Cover

Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology, and therapeutic applications. It also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. The book begins with an overview of fundamental glycobiology, followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research. Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases, and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up, and analysis.

About the Author

Rita Ferreira has a degree and a PhD in Biochemistry. RF is Assistant Professor at University of Aveiro where she has been teaching courses related to biochemistry and biomedicine to both undergraduate and graduate students. RF develops research work in the field of muscle plasticity in pathophysiological conditions, including the evaluation of the impact of exercise training in cancer-induced muscle wasting using Omics approaches. She is particularly interested in the study of the preventive and therapeutic effect of physical activity in the setting of wasting conditions.

Dr. Pedro Fontes Oliveira, in 2004, earned his PhD degree in Biomedical Sciences, at the University of Porto, Portugal. In 2005, Pedro F. Oliveira started his post-doctoral fellowship at the University of Porto and began working on a new line of research now focused on reproductive biology, specifically in Sertoli cells ionic regulation. In 2009, Dr. Oliveira was selected to apply for the “Ciência 2008 Program through the Health Science Research Center, University of Beira Interior (CICS-UBI) and was hired as an Assistant Researcher. Currently Dr. Oliveira’s research interests include hormonal control and metabolic modulation of spermatogenesis, with emphasis on Sertoli cells hormonal modulation, ionic water transport, and mechanisms by which endocrine disorders and pathologies, namely Diabetes Mellitus, result in subfertility and infertility.

Rita Nogueira Ferreira has a graduation in Biochemistry (2010), a master’s degree in Biochemistry – specialization in Clinical Biochemistry (2012), and a PhD in Biochemistry (2017), obtained at the University of Aveiro (Portugal). She has been developing research work in the study of the molecular and cellular mechanisms associated with different pathological conditions (pulmonary arterial hypertension, heart failure, cancer, obesity) and related to the effect of pharmacological and non-pharmacological approaches (exercise training) in the prevention or treatment of these conditions, using proteomic approaches. Currently, she works as Junior Researcher at UnIC@RISE, Department of Surgery and Physiology from the Faculty of Medicine of the University of Porto, Portugal. She was awarded in the FCT Individual Call to Scientific Employment Stimulus (CEECIND) 2021 to proceed in the study of sexual dimorphism in cardiovascular pathophysiology. In particular, she is interested in exploring the sex differences in heart failure, as well as the adaptations to exercise training, aiming to improve heart failure management.

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