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Females Are Mosaics: X Inactivation and Sex Differences in Disease Second Edition
Author(s): Barbara Migeon (Author)
- Publisher: OUP USA
- Publication Date: 5 Dec. 2013
- Edition: Second
- Language: English
- Print length: 328 pages
- ISBN-10: 0199927537
- ISBN-13: 9780199927531
Book Description
Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome, females have two X chromosomes in every cell. Much has been written about the Y chromosome and its role in inducing maleness. This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. This new edition reflects research advances from the six years since the widely praised first edition. New advances include knowledge of species differences in mammalian X inactivation processes and silencing of the inactive X chromosome.
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About the Author
Barbara Migeon, MD, has held fellowships in pediatrics, endocrinology and genetics. She is board certified in pediatrics, biochemical genetics and cytogenetics. She was the founding director of the Hopkins PhD Program in Human Genetics. Her research has been focused on the molecular mechanisms of X inactivation in human cell and the clinical consequences of the single active X chromosome.
