Extracellular Matrix Biomimicking for Theranostics

This book explores the rapidly advancing intersection of biomaterials science and clinical diagnostics and therapeutics, collectively known as Theranostics. It focuses on the design, development, and translational application of extracellular matrix (ECM)–mimicking biomaterials as next-generation platforms for improving diagnostic accuracy, therapeutic delivery, and treatment predictability—particularly in cancer, tissue regeneration, and personalized medicine.

At its core, the book examines how biomimetic ECM systems replicate the structural, biochemical, and mechanical cues of native tissues, enabling more physiologically relevant in vitro and in vivo environments. By emulating the dynamic and hierarchical architecture of the ECM, these materials demonstrate significant potential in enhancing drug delivery, predicting therapeutic efficacy, and facilitating tissue repair and regeneration.

The book provides in-depth coverage of advanced fabrication strategies, including 3D bioprinting, molecular self-assembly, and decellularization-based approaches, for creating functional ECM analogs. Each chapter presents case studies, experimental findings, and applied methodologies, illustrating how ECM biomimicry is being integrated into theranostic systems across diverse biomedical applications. A distinguishing feature of this volume is its incorporation of high-quality illustrations, 3D renderings, and comprehensive tables, which visually elucidate complex mechanisms, material architectures, and data interpretation.

This book offers a holistic framework for leveraging ECM biomimicking in Theranostics by bridging fundamental biomaterials research with applied clinical translation. It serves as a valuable resource for biomaterials scientists, bioengineers, clinicians, and translational researchers seeking to stay at the forefront of regenerative medicine, cancer therapy, and diagnostic innovation.

Dr. Deepa Suhag is an Assistant Professor at the Amity School of Applied Sciences, Amity University Haryana, India. She has authored several peer-reviewed research articles published in leading international journals and has filed six patents, including two granted patents by the Government of India, as of now. One of her granted patents, titled “Method for preparation of highly fluorescent biocompatible sulphur-doped graphene quantum dots from affordable agro-industrial bio-waste cane molasses using hydrothermal synthesis for bioimaging applications,” was awarded on 19 May 2022. Dr. Suhag has also authored research monographs and edited scholarly books. She is also the recipient of competitive research funding from prestigious Indian government agencies, including DRDO and ICMR, supporting her work in advanced biomaterials and regenerative medicine. Her research interests include biomaterials engineering, wound healing, and tissue regeneration, with a strong focus on developing translational, clinically relevant biomimetic materials.