Enzyme Catalysis in Organic Synthesis, 3 Volume Set 3rd, Completely Revised and Enlarged Edition

The use of enzymes in organic synthesis in both academia and industry has changed from being a seldom-used technique to common practice. The power of the technology results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology in organic synthesis. This book explains how and why enzymatic catalysis has developed into the crucial synthetic tool for the chemist that it is.

A major driver in research and development in the chemical industry is to employ environmentally friendly processes, often named “green” or “sustainable”. Synthetic biology is also facilitated by enzyme catalysis which offers fascinating opportunities in this respect and is, and will continue to be, one of the most important tools available to scientists aiming to maintain product and process development while protecting the environment and its resources.

The new edition of this renowned handbook retains the classification of biocatalytic transformations by reaction type, and this comprehensive three-volume set guides the user through the latest innovations, provides analysis of important new trends, and will be an indispensable companion for all practitioners of chemical synthesis.

Herbert Waldmann, a pioneer in the field, comments in his foreword of this third edition: “It is not only an invaluable source of knowledge and references, it also embodies a treasure that consists of a multitude of findings not yet exploited by the scientific community.” A must-have for all scientists working in (bio)catalysis and modern organic chemistry.

Harald Gröger is since 2006 Professor for organic chemistry at the University of Erlangen-Nürnberg, Germany. He studied chemistry at the Universities of Erlangen-Nürnberg and Oldenburg, before he did his postdoc with Masakatsu Shibasaki at the University of Tokyo. He worked from 1998 to 2006 in industry, e.g. as senior project manager for White Biotechnology of Degussa. He received several awards, like the Degussa innovation prize for new products (2003) and for new and optimized processes (2005), the Thieme award in 2007 and the German business sectors innovation prize (2004). His research interests are enzyme catalyzed organic synthesis, design and use of biomimetic chemocatalysts as well as sustainable chemistry.

Oliver May is Competence Manager Biocatalysis and responsible for coordinating biocatalysis related activities of DSM Pharmaceutical Products. Before joining DSM in April 2006, he was with Degussa (now Evonik) in various functions; latest as General Manager of Degussa’s Service Center Biocatalysis. He was educated in Germany, receiving a PhD degree in Technical Biology from the University of Stuttgart where he worked at the Institute of Biochemical Engineering for Prof. C. Syldatk and at the German Center for Biotechnology in Braunschweig with Prof. D. Schomburg. He joined Caltech as a postdoc in 1998 where he worked until 2000 in the group of Prof. F.H. Arnold on directed evolution of enzymes. Oliver May has authored more than 30 scientific contributions in Journals and Books and more than 15 patent applications. He his team was awarded several innovation awards on hydantoinase technology, whole-cell processes and the latest on recombinant pig liver esterase in its application for production of a pharma intermediate.