Wow! eBookDevelopmental and Reproductive Toxicology Vol.3
Pub. Date: 14 December 2011
Print ISBN-13: 9781841847771
Print ISBN: 1841847771
Product ID: 834087
Language: English
# of pages: 872
Summary
This third edition of Developmental and Reproductive Toxicology: A Practical Approach provides comprehensiveguidance for planning and conducting developmental and reproductive toxicity studies and interpreting theirresults for regulatory purposes. It is intended to be a comprehensive guide to the practice of developmentaland reproductive toxicology, providing insights gained from hands-on experience. It will be especially useful forregulatory scientists or anyone responsible for chemical testing.
Table of Contents
| Front Cover | Contents | Contributors | Preface | About the editor | Chapter 1 Principles of developmental toxicology revisited | Chapter 2 Experimental approaches to evaluate mechanisms of developmental toxicity | Chapter 3 Experimental approaches to evaluate mechanisms of reproductive toxicity | Chapter 4 Mateally-mediated effects on development | Chapter 5 Pateally-mediated effects on development | Chapter 6 Comparative gestational milestones in vertebrate development | Chapter 7 Developmental toxicity testing—Methodology | Chapter 8 Reproductive toxicity testing—M ethodology | Chapter 9 Significance, reliability, and interpretation of developmental and reproductive toxicity study findings | Chapter 10 Nonclinical juvenile toxicity testing | Chapter 11 Neurobehavioral testing for developmental toxicity | Chapter 12 The U.S. EPA Endocrine Disruptor Screening Program: The Tier 1 Screening Battery | Chapter 13 In vitro screening methods for developmental toxicology | Chapter 14 Approaches for evaluation of mode of action | Chapter 15 Functional genomics and proteomics in developmental and reproductive toxicology | Chapter 16 Nonhuman primates as preclinical models for developmental and reproductive toxicity evaluation | Chapter 17 Developmental and reproductive safety assessment of biopharmaceuticals | Chapter 18 Developmental immunotoxicity testing | Chapter 19 Developmental and reproductive safety testing of vaccines | Chapter 20 Use of toxicokinetics in developmental and reproductive toxicology | Chapter 21 Understanding statistics in developmental and reproductive toxicology | Chapter 22 Quality conces for reproduction and developmental toxicology studies | Chapter 23 Predictive modeling and computational toxicology | Chapter 24 Critical evaluation of current developmental toxicity testing strategies—A case of babies and their bathwater | Chapter 25 Perspectives on the developmental and reproductive toxicity guidelines | APPENDIX 1 S5A (and Amendments) Guidance | APPENDIX 2 ICH S6 Guidance and ICH M3 Guidance | APPENDIX 3 OECD Guidelines for the Testing of Chemicals | Chapter 26 Human studies—Epidemiologic techniques in developmental and reproductive toxicology | Chapter 27 Developmental and reproductive toxicity risk assessment for environmental agents | Chapter 28 Perspectives in risk assessment—Drug and vaccine safety | Chapter 29 Developmental and reproductive toxicity evaluation under the European Union REACH regulations | Appendix: Terminology of developmental abnormalities in common laboratory mammals (version 2) | Index | Back Cover
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