Degradation Rate of Bioresorbable Material: Prediction and Evaluation

Degradation Rate of Bioresorbable Material: Prediction and Evaluation book cover

Degradation Rate of Bioresorbable Material: Prediction and Evaluation

Author(s): F.J. Buchanan (Author, Editor)

  • Publisher: Woodhead Publishing Ltd
  • Publication Date: 29 Sept. 2008
  • Language: English
  • Print length: 420 pages
  • ISBN-10: 1845693299
  • ISBN-13: 9781845693299

Book Description

Bioresorbable materials could be employed to provide significant advances in drug delivery systems and medical implants. The rate of material degradation is critical to performance of both implants and the controlled release of drugs. Degradation rate of bioresorbable materials: prediction and evaluation addresses the practicalities of this subject in detail. The first section provides an overview of bioresorbable materials and the biological environment. Degradation mechanisms are reviewed in the second section in the book, followed by bioresorption test methods in the third part. The fourth section discusses factors influencing bioresorption; finally clinical applications are reviewed.

Key Features: comprehensively reviews the most pertinent techniques in safely predicting and evaluating the degradation rate of bioresorbable materials; addresses degradation mechanisms of commonly used materials; discusses factors influencing bioresorbability such as sterilisation and host response; reviews the current clinical applications of bioresorbable materials such as implant design and drug release.

Contents: Part 1 Introduction: An overview of bioresorbable materials; The biological environment for bioresorbable materials. Part 2 Degradation mechanisms: Synthetic bioresorbable polymers; Natural bioresorbable polymers; Bioresorbable ceramics. Part 3 Bioresorption test methods: In-vitro physicochemical test methods to evaluate bioresorbability; In-vitro biological test methods to evaluate bioresorbability; In-vivo test methods to evaluate bioresorbability; Modelling of the degradation processes for bioresorbable polymers. Part 4 Factors influencing bioresorption: Influence of processing, sterilisation and storage on bioresorbability; Influence of porous structure on bioresorbability: Tissue engineering scaffolds; Part 5 Clinical application: Influence of clinical application on bioresorbability: Host response; Scaffold and implant design: Considerations relating to characterization of biodegradibility and bioresorbability; Drug release from bioresorbable materials.

Editorial Reviews

From the Back Cover

Bioresorbable materials are extensively used for a wide range of biomedical applications from drug delivery to fracture fixation, and may remain in the body for weeks, months or even years. Accurately predicting and evaluating the degradation rate of these materials is critical to their performance and the controlled release of bioactive agents. Degradation rate of bioresorbable materials: prediction and evaluation provides a comprehensive review of the most important techniques in safely predicting and evaluating the degradation rate of polymer, ceramic and composite based biomaterials.

Part one provides an introductory review of bioresorbable materials and the biological environment of the body. Chapters in Part two address degradation mechanisms of commonly-used materials such as polymers and ceramics. This is followed by chapters on bioresorption test methods and modelling techniques in Part three. Part four discusses factors influencing bioresorbability such as sterilisation, porosity and host response. The final section reviews current clinical applications of bioresorbable materials.

With its distinguished editor and multidisciplinary team of international contributors, Degradation rate of bioresorbable materials: prediction and evaluation will provide a unique and valuable reference for biomaterials scientists, engineers and students as well as the medical community.

About the Author

Dr Fraser Buchanan is a Senior Lecturer in the School of Mechanical and Aerospace Engineering at Queens University Belfast. He is highly regarded for his expertise in developing and testing synthetic biomaterials.

View on Amazon

电子书代发PDF格式价格30我要求助
未经允许不得转载:Wow! eBook » Degradation Rate of Bioresorbable Material: Prediction and Evaluation