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Coarse-Grained Modelling of DNA and DNA Self-Assembly 2012th Edition
Author(s): Thomas E. Ouldridge (Author)
- Publisher: Springer
- Publication Date: 7 July 2012
- Edition: 2012th
- Language: English
- Print length: 188 pages
- ISBN-10: 9783642305160
- ISBN-13: 9783642305160
Book Description
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker ― the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
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From the Back Cover
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker ― the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
