Cellular Senescence and Brain Aging: Mechanisms, Therapeutic Strategies, and Implications for Neurodegenerative Diseases

The book examines the cellular senescence in brain aging processes and its effects on three major neurodegenerative conditions: Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. It discusses basic aging mechanisms, including oxidative stress, mitochondrial dysfunction, and neuroinflammation, before moving on to current treatments such as senolytics and autophagy modulators.

The book is divided into several chapters, with specific sections dedicated to experimental approaches, detection methods, and disease-by-disease analysis of cellular senescence effects. A specific chapter explores the clinical potential of senescence-targeting therapies and discusses upcoming study pathways.

This publication is aimed at researchers in neuroscience, clinicians, graduate students, neuroscientists, and neuropharmacology professionals involved in the assessment of age-related disorders. It delivers thorough expertise by combining research evidence on brain aging with methods to combat cognitive decline. The structured system within this publication creates connections between basic research and medical implementation, providing essential knowledge for treating neurodegeneration.

Dr. Gaurav Gupta holds a doctoral degree from Pacific University, Udaipur, Rajasthan, India. He has more than thirteen years of experience in molecular and biochemical pharmacology, including neurological disorders and respiratory diseases. Dr. Gupta is currently associated as an Adjunct Professor with the Centre for Research Impact & Outcome at Chitkara College of Pharmacy, Chitkara University, Rajpura, and the Centre for Global Health Research at Ajman University, UAE. Dr. Gupta is a highly accomplished pharmacologist with expertise in neurodegenerative diseases, cellular senescence, and molecular mechanisms of brain aging. Listed among the World’s Top 2% Scientists (Stanford University, 2020–2024), Dr. Gupta has authored over 700 peer-reviewed publications, with a cumulative impact factor exceeding 5000, an H-index of 64, and more than 19,800 citations. His research focuses on the roles of cellular senescence, oxidative stress, and neuroinflammation in Alzheimer’s, Parkinson’s, and other neurodegenerative diseases, as well as respiratory diseases. His editorial contributions include Springer volumes on inflammatory lung diseases, epigenetics, and molecular pharmacology.