Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is a cutting-edge resource for the major biophysical methods that are – or soon will be- the major techniques used in the field. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Each chapter is dedicated to a specific approach, describing the method involved, highlighting the experimental procedure and/or the basic principles, offering an up-to-date understanding of what is measured, what can be deduced from the measurements, as well as the limitations of each procedure.
Following an introduction, further sections discuss structural approaches, molecular interaction and large assemblies, dynamics and spectroscopes, finishing off with an exploration of structure-function relationships in whole cells.
From the Back Cover
Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is a cutting-edge resource for the major biophysical methods that are – or soon will be- the major techniques used in the field. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Each chapter is dedicated to a specific approach, describing the method involved, highlighting the experimental procedure and/or the basic principles, offering an up-to-date understanding of what is measured, what can be deduced from the measurements, as well as the limitations of each procedure.
Following an introduction, further sections discuss structural approaches, molecular interaction and large assemblies, dynamics and spectroscopes, finishing off with an exploration of structure-function relationships in whole cells.
About the Author
Professor Eva Pebay-Peyroula carried out her PhD in molecular physics in the SNCI-CNRS Grenoble in 1986, where she continued to work during her post-doc. In 1991 she was made professor at the Universite Joseph Fourier, and in 2001 set up the Membrane Protein Laboratory in the Institute for Structural Biology, Grenoble, where she also serves as director of the institute. In 2004 she was elected a member of the French Academy of Science, and she has won the Universite Joseph Fourier gold medal award in 2004 and the silver medal of the CNRS in 2005.
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