Chromium exists in nature as complexes of two stable oxidation states – trivalent chromium(III) and hexavalent chromium(VI). Although trivalent chromium is required in trace amounts for sugar and lipid metabolism in humans and its deficiency may cause a disease called chromium deficiency; hexavalent chromium is toxic and carcinogenic. As chromium compounds were used in dyes and paints and the tanning of leather, these compounds are often found in soil and groundwater at abandoned industrial sites, now needing environmental cleanup and remediation.
The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology takes a critical look at what the biochemical data indicate about chromium’s role in the body and the biological mechanisms of its toxicology. Topics covered include:
What do we know about the biochemical roles and mechanisms of chromium?
Is chromium an essential element in the mammalian diet?
Is chromium(III) effective as a nutraceutical, a therapeutic agent, and as a supplement in animal feed?
What is the biochemistry behind the toxicology of chromium(III) and chromium(VI):the mechanisms of metabolism, genetic and epigenetic effects, and disruption of cell signalling?
What are the current chromium(VI) policies and positions from regulatory agencies?
The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology is an important contribution to the bioinorganic and trace element biochemical fields which will find a place on the bookshelves of bioinorganic chemists, biochemists, inorganic chemists, toxicologists, nutritionists and regulatory affairs professionals.
Editorial Reviews
From the Inside Flap
Chromium exists in nature as complexes of two stable oxidation states – trivalent chromium(III) and hexavalent chromium(VI). Although chromium(VI) is a well known human toxin and potential carcinogen, the effects of chromium(III) on the body are less well known. Chromium(III) has been proposed to be required in trace amounts for proper sugar and lipid metabolism in humans, and its deficiency has been proposed to result in symptoms similar to diabetes. Chromium(III) compounds have been popular nutraceuticals, claimed to aid weight loss and muscle mass enhancement. However, the nutritional essentialness of chromium(III) has been questioned, while chromium(III) has been proposed to serve as a possible therapeutic agent to treat diabetes and insulin resistance. The use of chromium(III) compounds as nutraceutical or therapeutic agents has raised questions about the toxicity of these compounds.
The Bioinorganic Chemistry of Chromium takes a critical look at what the biochemical data indicate about chromium’s role in the body and the biological mechanisms of its potential toxicology. Topics covered include:
The Bioinorganic Chemistry of Chromium is an important contribution to the bioinorganic and trace element biochemical fields which will find a place on the bookshelves of bioinorganic chemists, biochemists, inorganic chemists, toxicologists, nutritionists and regulatory affairs professionals.
what do we know about the biochemical roles and mechanisms of chromium?
the current status of chromium as defined by government agencies or public foundations
is chromium an essential element in the mammalian diet?
is chromium(III) effective as a nutraceutical, a therapeutic agent, and as a supplement in animal feed?
what is the biochemistry behind the potential toxicology of chromium(III): the mechanisms of metabolism and effect on cell signalling?
what are the current chromium(III) policies and positions from regulatory agencies?
From the Back Cover
Chromium exists in nature as complexes of two stable oxidation states – trivalent chromium(III) and hexavalent chromium(VI). Although chromium(VI) is a well known human toxin and potential carcinogen, the effects of chromium(III) on the body are less well known. Chromium(III) has been proposed to be required in trace amounts for proper sugar and lipid metabolism in humans, and its deficiency has been proposed to result in symptoms similar to diabetes. Chromium(III) compounds have been popular nutraceuticals, claimed to aid weight loss and muscle mass enhancement. However, the nutritional essentialness of chromium(III) has been questioned, while chromium(III) has been proposed to serve as a possible therapeutic agent to treat diabetes and insulin resistance. The use of chromium(III) compounds as nutraceutical or therapeutic agents has raised questions about the toxicity of these compounds.
The Bioinorganic Chemistry of Chromium takes a critical look at what the biochemical data indicate about chromium’s role in the body and the biological mechanisms of its potential toxicology. Topics covered include:
The Bioinorganic Chemistry of Chromium is an important contribution to the bioinorganic and trace element biochemical fields which will find a place on the bookshelves of bioinorganic chemists, biochemists, inorganic chemists, toxicologists, nutritionists and regulatory affairs professionals.
what do we know about the biochemical roles and mechanisms of chromium?
the current status of chromium as defined by government agencies or public foundations
is chromium an essential element in the mammalian diet?
is chromium(III) effective as a nutraceutical, a therapeutic agent, and as a supplement in animal feed?
what is the biochemistry behind the potential toxicology of chromium(III): the mechanisms of metabolism and effect on cell signalling?
what are the current chromium(III) policies and positions from regulatory agencies?
About the Author
Professor John B. Vincent, Department of Chemistry, The University of Alabama, USA Professor Vincent has been working in the area of the bioinorganic chemistry of chromium(III) for nearly 20 years. He has ~125 peer-reviewed publications, book chapters, review articles, and books and 9 patents. He has recently completed a general chemistry laboratory manual for Pearson/Prentice Hall; the second edition of this manual will appear in early 2010. He has presented his research on chromium at numerous regional, national, and international meetings.
Professor Diane M. Stearns, Department of Chemistry and Biochemistry, Northern Arizona University, USA Professor Stearns is a metal toxicologist and has been working in the field of inorganic biochemistry and metal toxicology for over 20 years. She has been teaching graduate courses in toxicology, biochemistry, and cancer biology for over 12 years. She has published 23 peer-reviewed research articles and 8 invited reviews and book chapters on metals. She has presented results of metal toxicology research at numerous scientific conferences and invited seminars.
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