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Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy 2012th Edition
Author(s): Matthias J.N.Junk (Author)
- Publisher: Springer
- Publication Date: 5 Jan. 2012
- Edition: 2012th
- Language: English
- Print length: 228 pages
- ISBN-10: 364225134X
- ISBN-13: 9783642251344
Book Description
In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
Editorial Reviews
From the Back Cover
In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
About the Author
Hans-Otto Günthergeb. 1948 in Gelsenkirchen, ist nach Lehrstuhlvertretungen an den Universitäten Bonn und Bayreuth und einer Professur an der Universität Wien seit 1993 Inhaber eines Lehrstuhls für Betriebswirtschaftslehre und Produktionsmanagment an der Technischen Universität Berlin. Seine Arbeitsschwerpunkte sind in der Produktionslogistik sowie die operative Planung automatisierter Produktionssysteme.Horst Tempelmeiergeb. 1952 in Lübbecke/Westf., ist nach Professuren an der Technischen Hochschule Darmstadt und der Technischen Universität Braunschweig seit 1993 Inhaber einer Professur für Produktionswirtschaft an der Universität Köln. Seine Arbeitsschwerpunkte sind die Produktionsplanung und -steuerung sowie Probleme der Gestaltung des Betriebs von flexiblen Produktionssystemen.
