Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications
Author(s): Rosaleen Anderson (Author), Paul W. Groundwater (Author), Adam Todd (Author), Alan Worsley (Author)
Publisher: Wiley
Publication Date: 22 Jun. 2012
Edition: 1st
Language: English
Print length: 376 pages
ISBN-10: 0470972440
ISBN-13: 9780470972441
Book Description
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function.
Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements.
Agents covered include:
agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents
agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim
agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
agents targeting cell wall synthesis – β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin
Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
Editorial Reviews
From the Inside Flap
Antibacterial Agents is an essential guide to an important class of chemotherapeutic drugs. In this full colour volume, compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. Topics are presented using an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects including links to current guidelines, significant drug interactions, cautions and contraindications, prodrugs and future improvements. This modern text summarises all the current knowledge on antibacterial drugs, and each chapter includes full colour diagrams and a set of key points for easy reference.
Agents covered include:
agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents
agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim
agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
agents targeting cell wall synthesis – β-lactam and glycopeptide antibiotics, cycloserine, isoniazid, and daptomycin
Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
From the Back Cover
Antibacterial Agents is an essential guide to an important class of chemotherapeutic drugs. In this full colour volume, compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. Topics are presented using an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects including links to current guidelines, significant drug interactions, cautions and contraindications, prodrugs and future improvements. This modern text summarises all the current knowledge on antibacterial drugs, and each chapter includes full colour diagrams and a set of key points for easy reference.
Agents covered include:
agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents
agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim
agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
agents targeting cell wall synthesis – β-lactam and glycopeptide antibiotics, cycloserine, isoniazid, and daptomycin
Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
About the Author
Professor Rosaleen Anderson, Professor of Pharmaceutical Chemistry, Sunderland Pharmacy School, University of Sunderland, UK
Professor Paul Groundwater, Professor of Medicinal Chemistry, Faculty of Pharmacy, The University of Sydney, Australia
Dr Adam Todd, Senior Lecturer in Pharmacy Practice, Sunderland Pharmacy School, University of Sunderland, UK
Dr Alan Worsley, Principal Lecturer in Pharmacy Practice, Sunderland Pharmacy School, University of Sunderland, UK
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