Advanced Delivery and Therapeutic Applications of RNAi
Author(s): Kun Cheng (Editor), Ram I. Mahato
- Publisher: Wiley
- Publication Date: 17 May 2013
- Edition: 1st
- Language: English
- Print length: 536 pages
- ISBN-10: 1119976863
- ISBN-13: 9781119976868
Book Description
Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. This book covers all essential aspects involved in the development of RNAi therapeutics, providing detailed guidance on the challenges and opportunities of bringing RNAi technologies from bench to clinic. It explores the design and mechanism of RNAi molecules, delivery strategies, and therapeutic applications in various diseases. Preclinical, regulatory, market, and intellectual aspects of RNAi technologies are also covered.
Editorial Reviews
From the Inside Flap
RNA interference (RNAi) is a process in living cells whereby small double stranded RNA interferes with the expression of specific genes with complementary nucleotide sequence. Like many nucleic acid-based therapies, RNAi has great potential in treating various life-threatening diseases. However, the poor stability and cellular uptake of RNAi molecules remain considerable barriers to their efficient delivery which is paramount to a successful therapy. This book provides a comprehensive introduction to RNAi delivery, then goes on to discuss different delivery strategies, and concludes with current applications in various diseases. It covers:
- Mechanisms, Barriers, and Analysis of RNAi Delivery
- Nonclinical Safety Assessments and Clinical Pharmacokinetics: A Regulatory Perspective
- Bioconjugation of siRNA for Site Specifi c Delivery
- Nanoscale Delivery Systems for RNAi
- Environmentally-Responsive Delivery Systems for RNAi
- Light-sensitive RNAi
- Viral-Mediated Delivery of shRNA and miRNA
- RNAi applications in Cancer Therapy, Liver Diseases, Hepatitis B, and Ocular Disease
- miRNA as therapeutic agents and targets
Advanced Delivery and Therapeutic Applications of RNAi combines the essential aspects of developing RNAi therapeutics from bench to clinic, and is invaluable for researchers working on RNAi, drug discovery and delivery, biomedical engineering, biomaterials, molecular biology, and biotechnology.
From the Back Cover
RNA interference (RNAi) is a process in living cells whereby small double stranded RNA interferes with the expression of specific genes with complementary nucleotide sequence. Like many nucleic acid-based therapies, RNAi has great potential in treating various life-threatening diseases. However, the poor stability and cellular uptake of RNAi molecules remain considerable barriers to their efficient delivery which is paramount to a successful therapy. This book provides a comprehensive introduction to RNAi delivery, then goes on to discuss different delivery strategies, and concludes with current applications in various diseases. It covers:
- Mechanisms, Barriers, and Analysis of RNAi Delivery
- Nonclinical Safety Assessments and Clinical Pharmacokinetics: A Regulatory Perspective
- Bioconjugation of siRNA for Site Specifi c Delivery
- Nanoscale Delivery Systems for RNAi
- Environmentally-Responsive Delivery Systems for RNAi
- Light-sensitive RNAi
- Viral-Mediated Delivery of shRNA and miRNA
- RNAi applications in Cancer Therapy, Liver Diseases, Hepatitis B, and Ocular Disease
- miRNA as therapeutic agents and targets
Advanced Delivery and Therapeutic Applications of RNAi combines the essential aspects of developing RNAi therapeutics from bench to clinic, and is invaluable for researchers working on RNAi, drug discovery and delivery, biomedical engineering, biomaterials, molecular biology, and biotechnology.
About the Author
Professor Kun Cheng, Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, USA
Professor Cheng’s research interests include the delivery and therapeutic applications of RNAi for breast cancer, prostate cancer, liver diseases, and type I diabetes. He has been working in the area of nucleic acids since 2002. He is co-editor of Advanced Drug Delivery with Dr. Ashim Mitra and Dr. Chi Lee (Wiley, 2012). He has also co-edited a themed issue entitled “siRNA Delivery” with Dr. Ram Mahato for the journal Molecular Pharmaceutics, and has developed and taught a graduate course entitled “Protein and Nucleic Acid Drug Delivery”.
Professor Ram I. Mahato, Department of Pharmaceutical Sciences, School of Pharmacy, University of Tennessee Health Science Center, USA
Professor Mahato is a full professor of Pharmaceutics and Drug/Gene Delivery at the University of Tennessee Health Science Center Memphis. He is the author or co-author of 85 peer reviewed articles and book chapters. He has also edited/written five books and six special journal issues. He is a Special Features Editor of Pharmaceutical Research and on the editorial board of several journals. His research interest includes delivery and targeting of small molecules, oligonucleotides, siRNA and genes.
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