Adenoviral Vectors for Gene Therapy 3rd Edition

The fully updated and expanded third edition covers the basic biology of adenoviruses and highlights the potential use of adenoviral vectors for the treatment of disease, including their construction, propagation, and purification, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models. The book also considers the regulatory issues surrounding human clinical gene therapy trials. New chapters include adenoviral vaccines for veterinary applications, adenoviruses for gene editing, nonhuman primate adenoviruses, COVID-19 vaccines, vaccine applications, and oncolytic adenoviruses for antitumor immunization. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

• Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors
• Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement
• Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
• Discusses the utility of adenoviral vectors in animal disease models
• Considers Food and Drug Administration regulations for human clinical trials