Congenital Heart Diseases:The Broken Heart:Clinical Features, Human Genetics and Molecular Pathways (Advances in Experimental Medicine and Biology, 1441)

by: Silke Rickert-Sperling (Editor),Robert G. Kelly (Editor),Nikolaus Haas (Editor)&0more

Publisher: Springer

Edition: Second Edition 2024

Publication Date: 2024/6/18

Language: English

Print Length: 1146 pages

ISBN-10: 3031440862

ISBN-13: 9783031440861

Book Description

This 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways.The book is divided into three parts:an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques.Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to lea more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.

About the Author

This 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways.The book is divided into three parts:an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques.Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to lea more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.